Reducing spine-related disability must become a national priority. This is the vision and mission of the Spine Foundation. The Spine 10 X 25 Initiative has placed the target on the horizon, by setting the goal of reducing spine-related disability in the United States by 10% by the year 2025. The Spine Foundation can confidently bring the Spine 10 X 25 Initiatives to life by instituting greater societal awareness, creating a coalition of vested medical and nonmedical stakeholders, and establishing a national imperative through educational efforts on Capitol Hill.